Factor replacement therapies
This form of treatment replaces the missing clotting factor in blood to help with clotting and provide protection from bleeds.
How hemophilia is treated.
Everyone has different needs when it comes to their hemophilia treatment. Knowing what options are available and understanding how they work can help you have productive conversations with your care team and find the treatment that can open up more possibilities for you.
Types of treatment
There are several different ways of treating hemophilia. Work with your doctor to better understand how lifestyle, hemophilia severity, and other circumstances may inform how to manage your condition.
Non-factor therapies
Non-factor therapies aim to enhance clotting by mimicking the activity of clotting factors to provide ongoing prophylactic bleed prevention.
Treating hemophilia with factor replacement therapy
Within factor replacement therapy, there are a few key terms to know and options to consider.
Prophylaxis
Infusion treatments are given preventatively at regular intervals.
On-demand
Treatment is delivered as bleeds occur.
Standard half-life (SHL)
SHL therapies are therapies that generally have a half-life of 8-12 hours for factor VIII and 18-40 hours for factor IX.
Extended half-life (EHL)
EHL therapies remain in the bloodstream about 1.5 times longer for factor VIII and up to 5 times longer for factor IX than an SHL, meaning infusions can be delivered less frequently.
Learn about an EHL treatment option for hemophilia A.
Let’s go
Learn about an EHL treatment option for hemophilia B.
Let’s goChoosing the right treatment for you
Learn about simple steps you can take to explore your options from Sanofi Community Relations and Education (CoRe) Managers.
Factoring in your hemophilia type
Every person is unique, and there are many things to consider when deciding on a hemophilia management strategy with your doctor. While hemophilia A and hemophilia B have similarities, there are important differences between the two that can affect treatment and management.
With hemophilia A, factor replacement therapy stays in the bloodstream. With hemophilia B, factor replacement may travel in and out of the bloodstream. A complete treatment assessment may include multiple ways of measuring factor activity levels and can help provide the full picture within the body.
In addition, your individual bleed rates, joint bleed prevention, and personal goals should be considered as part of treatment management discussions with your doctor.
Learn more
Remember: everyone’s body is different.
Age, weight, metabolism, and other elements can affect how quickly the body breaks down factor therapies. Hematologists can build a pharmacokinetics (PK) profile to get a sense of how severe your hemophilia is and the best way to manage it.
Learn more about PK and factor activity.Hemophilia voices
“I know living with hemophilia can be very frustrating, but it is important to recognize how far we have come as a community and to be thankful for the innovations and care we have today. I believe it will only get better for us.”
